Recent research found that combination of two drugsВ can destroy the deadliest form of skin cancer, even if it is diagnosed at a late stage. The study wasВ published in the New England Journal of Medicine, a drug combination by Bristol-Myers Squibb was shown to reduce melanoma tumors in 58% of patients by one third over the course of one year.
Results of the study shows thatВ the cocktail of two drugs can wipe out all traces of melanoma in more than one in five patients, even if the cancer has spread to other parts of the body. (1)
Melanoma is one of the most serious skin cancer. From 2013В more than 14,500 people in the UK developed melanoma and 2100 already died.В In Australia, more than 12,000 cases of melanoma were reported in 2012 and the Melanoma Institute of Australia says one person every six hours will die from melanoma.
The study was made onВ 142 patients with advanced melanoma either the drug ipilimumab alone or in combination with a similar treatment called nivolumab.
The study wasВ called CheckMate. The conclusion isВ 69 per cent of patients given the combination were alive two years later, compared to 53 per cent of those given ipilimumab alone.
When the two drugs are used together, the tumour was destroyed in 22 per cent of patients. But, none of theВ patients who were given just ipilimumab had such a remarkable response.
Dr James Larkin said the nivolumab and ipilimumab drugs have changed survival expectations in advanced melanoma. (2)
British expert Dr James Larkin, consultant medical oncologist at the Royal Marsden Hospital, has treated patients with the drugs as part of another on-going trial.
Dr Larkin said: “Both nivolumab and ipilimumab have changed survival expectations in advanced melanoma over the last few years and these latest data show us that combining these two immunotherapies is an effective two-pronged attack against the cancer.
“The overall survival rates observed using the regimen of nivolumab plus ipilimumab are very promising and provide further hope for patients and their families affected by this disease.”
Prof Richard Marais, from Cancer Research UK, said the results were “exciting” and “offer new hope to melanoma patients and their families”. (3)
However, he added: “It’s important to remember that there’s an increased likelihood of severe side effects when these drugs are combined.
“We need to identify which patients are most likely to benefit from this combination and also which patients are most likely to experience the side effects.
“That will help doctors to ensure each patient gets the best treatment they need.”