вЂњIn one of the largest studies involving people who stay healthy into old age, researchers found some interesting clues behind how they get that way вЂ” and it has little to do with genes for longevity.вЂќ (1)
There are a lot of research studies about different disease, but lacking studies aboutВ longevity. The main reasonВ isВ the fact that people withВ a disease showsВ genetic or other biological changes which are responsible for their condition, compared to healthy people with no biological orВ genetic changes.
The studyВ “Wellderly”В has provided its first glimpse of the genetic secrets behind healthy aging to 80 and beyond. (2)
The research was made onВ more than 1,400 people age 80 to 105 withoutВ serious chronic medical condition, such as Alzheimer’s, cardiovascular disease or diabetes.В It’s the first systematic effort to uncover the genetic mechanisms underlying healthy aging, as opposed to the conventional emphasis on finding causes of disease.
The study showsВ a possible link between long-term brain health and protection from chronic diseases such as cancer, heart disease and diabetes, the researchers said. (3)
“For many decades, we have searched for the genetic causes of disease in sick individuals,” said Eric Schadt, founding director of the Icahn Institute for Genomics and Multiscale Biology at Mount Sinai in New York City.
According toВ Schadt, who was not involved inВ the study:В “presents an attractive alternative by studying those who are well in order to uncover the solutions nature has provided to protect us against disease.”
When the stretch of DNA from a patient in the study was swapped into the sickly stem cells and then used to make arterial muscle cells, they вЂњhad a totally different look,вЂќ saidВ Eric Topol of San DiegoвЂ™s Scripps Translational Science Institute and reported today in the journal Cell. вЂњWe can restore heart diseased people to healthy peopleвЂ”in a dish.вЂќ (4)