“In one of the largest studies involving people who stay healthy into old age, researchers found some interesting clues behind how they get that way — and it has little to do with genes for longevity.” (1)
There are a lot of research studies about different disease, but lacking studies about longevity. The main reason is the fact that people with a disease shows genetic or other biological changes which are responsible for their condition, compared to healthy people with no biological or genetic changes.
The study “Wellderly” has provided its first glimpse of the genetic secrets behind healthy aging to 80 and beyond. (2)
The research was made on more than 1,400 people age 80 to 105 without serious chronic medical condition, such as Alzheimer’s, cardiovascular disease or diabetes. It’s the first systematic effort to uncover the genetic mechanisms underlying healthy aging, as opposed to the conventional emphasis on finding causes of disease.
The study shows a possible link between long-term brain health and protection from chronic diseases such as cancer, heart disease and diabetes, the researchers said. (3)
“For many decades, we have searched for the genetic causes of disease in sick individuals,” said Eric Schadt, founding director of the Icahn Institute for Genomics and Multiscale Biology at Mount Sinai in New York City.
According to Schadt, who was not involved in the study: “presents an attractive alternative by studying those who are well in order to uncover the solutions nature has provided to protect us against disease.”
When the stretch of DNA from a patient in the study was swapped into the sickly stem cells and then used to make arterial muscle cells, they “had a totally different look,” said Eric Topol of San Diego’s Scripps Translational Science Institute and reported today in the journal Cell. “We can restore heart diseased people to healthy people—in a dish.” (4)